Search results for "Catechol-O-methyl transferase"

showing 10 items of 11 documents

Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-cont…

2013

Background The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is a strong candidate gene regarding the pathophysiology of tobacco dependence and smoking behavior. Because of rather conflicting results in previous studies, the purpose of the present study was to test for association between a functional genetic variant in the COMT gene (single nucleotide polymorphism [SNP] rs4680) and tobacco smoking behavior. Methods In a population-based case-control multicenter study designed for tobacco addiction research, a total of 551 cur…

AdultCandidate genemedia_common.quotation_subjectPopulationEuropean Continental Ancestry Groupgenetics [Catechol O-Methyltransferase]Single-nucleotide polymorphism610 Medicine & healthCatechol O-MethyltransferasePolymorphism Single NucleotideWhite PeopleGermanymental disordersSNPMedicineHumanseducationmedia_commonGeneticseducation.field_of_studyCatechol-O-methyl transferasebusiness.industryAddictionSmokingPublic Health Environmental and Occupational Healthgenetics [Smoking]Tobacco Use Disorder2739 Public Health Environmental and Occupational HealthMiddle Agedmedicine.diseaseCase-Control Studies10054 Clinic for Psychiatry Psychotherapy and Psychosomaticsddc:640genetics [Tobacco Use Disorder]businessAddictive behaviorrs4680
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The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser sti…

2010

Background: Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase ( COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional val158met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been…

AdultMaleGenotypePainSingle-nucleotide polymorphismStimulationCatechol O-MethyltransferaseGyrus CinguliCellular and Molecular NeuroscienceYoung Adultmedicinelcsh:PathologyHumansddc:610AlleleAnterior cingulate cortexCerebral CortexCatechol-O-methyl transferasePolymorphism Geneticmedicine.diagnostic_testResearchLasersChronic painMiddle Agedmedicine.diseaseMagnetic Resonance ImagingAnesthesiology and Pain Medicinemedicine.anatomical_structureCerebral cortexPositron-Emission TomographyMolecular MedicineFemaleFunctional magnetic resonance imagingPsychologyNeurosciencelcsh:RB1-214Molecular Pain
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The catechol-O-methyltransferase Val108/158Met polymorphism affects short-term treatment response to mirtazapine, but not to paroxetine in major depr…

2004

The catechol-O-methyltransferase (COMT) is a major degrading enzyme in the metabolic pathways of catecholaminergic neurotransmitters such as dopamine and norepinephrine. This study investigated whether the functionally relevant Val(108/158)Met gene variant is associated with differential antidepressant response to mirtazapine and/or paroxetine in 102 patients with major depression (DSM-IV criteria) participating in a randomized clinical trial with both drugs. In patients treated with mirtazapine, but not paroxetine, allelic variations in the COMT gene were associated with differential response. COMT(VAL/VAL) and COMT(VAL/MET) genotype carriers showed a better response than COMT(MET/MET)-bea…

AdultMaleTime FactorsMirtazapineMirtazapineMianserinPharmacologyCatechol O-Methyltransferaselaw.inventionMethionineRandomized controlled triallawDopamineGenotypeGeneticsmedicineHumansPharmacologyDepressive Disorder MajorCatechol-O-methyl transferasePolymorphism Geneticbusiness.industryHamilton Rating Scale for DepressionValineMiddle AgedParoxetineParoxetineMolecular MedicineAntidepressantFemalebusinessmedicine.drugThe pharmacogenomics journal
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Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catecholO-methyltransferase (COMT) in borderline person…

2008

Borderline personality disorder (BPD) is characterized by a heterogeneous symptomatology with instability in impulse control, interpersonal relationships and self-image. BPD patients display repeated self-injury, chronic suicidal tendencies and emotional dysregulation, mainly dysregulation of negative affect. In its etiology, genetic and environmental factors have been suggested. Recently, an investigation in male healthy volunteers found gene–gene effects of the catechol-O-methyl-transferase (COMT) low-activity (Met158) and the low-expression allele of the deletion/insertion (short/long or S/L, respectively) polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) on the…

AdultMalemedicine.medical_specialtySingle-nucleotide polymorphismCatechol O-MethyltransferasePolymorphism Single Nucleotidebehavioral disciplines and activitiesCellular and Molecular NeuroscienceGene FrequencyGene interactionBorderline Personality DisorderInternal medicinemental disordersGenotypemedicineHumansAllelePromoter Regions GeneticBorderline personality disorderAllelesGenetics (clinical)Serotonin transporterSerotonin Plasma Membrane Transport ProteinsGeneticsCatechol-O-methyl transferasebiologybusiness.industryMiddle Agedmedicine.diseasePsychiatry and Mental healthLogistic ModelsEndocrinology5-HTTLPRbiology.proteinFemalebusinessAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
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The catechol o-methyltransferase (COMT) val158met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in fem…

2009

Wagner S, Baskaya O, Anicker NJ, Dahmen N, Lieb K, Tadic A. The catechol o‐methyltransferase (COMT) val158met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD). Objective: We analyzed i) the effects of serious life events (SLE) on impulsive aggression, and ii) modulating effects of the COMT Val158Met polymorphism on the association between SLEs and impulsive aggression in borderline personality disorder (BPD). Method: One hundred and twelve female BPD patients from Germany were included in this study. Impulsive aggression was assessed by the Buss‐Durkee‐Hostility Inventory (BDHI). Result…

Child abusemedicine.medical_specialtyCatechol-O-methyl transferaseAggressionPoison controlImpulsivitymedicine.diseasebehavioral disciplines and activitiesGenetic determinismPsychiatry and Mental healthSexual abusemental disordersmedicinemedicine.symptomPsychiatryPsychologyBorderline personality disorderActa Psychiatrica Scandinavica
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Correspondence to Sand et al. “Critical Reappraisal of a Catechol-O-Methyltransferase Transversion Variant in Schizophrenia”

2010

GeneticsCatechol-O-methyl transferaseSchizophrenia (object-oriented programming)GenotypeBiologyTransversionBiological PsychiatryBiological Psychiatry
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The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control st…

2015

Background Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interaction between antioxidant vitamin intake and OS-related polymorphisms modulates gene-associated anthropometry in a Spanish population. Methods A total of 246 subjects with AO, and 492 age and gender matched non-AO subjects were included in the study. Anthropometric, biochemical, and OS parameters, and antioxidant dietary intake data were assessed using validated procedures. DNA from white blood cells was isolated and the genotype of seven polymorphisms from genes involved in …

MaleAntioxidantPolimorphismmedicine.medical_treatment:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Thioredoxins [Medical Subject Headings]Antioxidantes:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]AntioxidantsVitamin E intakeObesidad abdominalchemistry.chemical_compoundNutrigenomicsThioredoxinsPolymorphism (computer science):Anatomy::Cells::Blood Cells::Leukocytes [Medical Subject Headings]Risk FactorsGenotypeVitamin E:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyguanosine [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Micronutrients::Vitamins [Medical Subject Headings]:Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings]Abdominal obesityNutrigenómicaMedicine(all)AnthropometryAge FactorsGeneral MedicineAbdominal obesity:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity::Obesity Abdominal [Medical Subject Headings]Middle Aged:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Logistic Models [Medical Subject Headings]Waist circumferenceDietaFemale:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]medicine.symptomFactores de riesgoVitaminAdultmedicine.medical_specialtyGenotypeVitamina ECatechol-O-methyltransferaseBiology:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes Reporter [Medical Subject Headings]Catechol O-Methyltransferase:Chemicals and Drugs::Biological Factors::Pigments Biological::Carotenoids::Retinoids::Vitamin A [Medical Subject Headings]Polymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologySex FactorsInternal medicine:Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Antioxidants [Medical Subject Headings]medicinePerímetro abdominal:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference [Medical Subject Headings]:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 2-Ring::Benzopyrans::Vitamin E [Medical Subject Headings]HumansObesityPolymorphismThioredoxinAgedCatechol-O-methyl transferaseBiochemistry Genetics and Molecular Biology(all)Vitamin EResearchCase-control studyGenes informadores:Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics::Nutrigenomics [Medical Subject Headings]DietOxidative StressEndocrinologychemistrySpainOxidative stressCase-Control Studies:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::One-Carbon Group Transferases::Methyltransferases::Catechol O-Methyltransferase [Medical Subject Headings]:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::DNA [Medical Subject Headings]Genotipo
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Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylathion

2016

Background: Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Hydroxytyrosol-related foods have been shown to protect against cardiovascular disease (CVD).Objective: We investigated the associations between hydroxytyrosol and its biological metabolite, 3-O-methyl-hydroxytyrosol, also known as homovanillyl alcohol (HVAL), with CVD and total mortality.Design: We included 1851 men and women with a mean ± SD age of 66.8 ± 6 y at high risk of CVD from prospective cohort data. The primary endpoint was a composite of myocardial infarction, stroke, and death from cardiovascular causes; the secondary endpoint was all-cause mortality. Twenty-four-hour urinary h…

Malemedicine.medical_specialtyGenotypeMediterranean dietCatecholsMyocardial InfarctionMedicine (miscellaneous)Wine030204 cardiovascular system & hematologyCatechol O-MethyltransferaseLower riskMethylationGastroenterology03 medical and health scienceschemistry.chemical_compound0302 clinical medicinePhenolsCause of DeathInternal medicineHomovanillyl alcoholmedicineClinical endpointHumans030212 general & internal medicineProspective cohort studyOlive OilAgedNutrition and DieteticsCatechol-O-methyl transferasebusiness.industryHomovanillic AcidMiddle AgedPhenylethyl AlcoholDietStrokechemistryCardiovascular DiseasesHydroxytyrosolFemalebusinessBiomarkersrs4680The American Journal of Clinical Nutrition
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Inhibition of Peripheral Dopamine Metabolism and the Ventilatory Response to Hypoxia in the Rat

2014

Dopamine (DA) is a putative neurotransmitter in the carotid body engaged in the generation of the hypoxic ventilatory response (HVR). However, the action of endogenous DA is unsettled. This study seeks to determine the ventilatory effects of increased availability of endogenous DA caused by inhibition of DA enzymatic breakdown. The peripheral inhibitor of MAO – debrisoquine, or COMT – entacapone, or both combined were injected to conscious rats. Ventilation and its responses to acute 8 % O2 in N2 were investigated in a whole body plethysmograph. We found that inhibition of MAO augmented the hyperventilatory response to hypoxia. Inhibition of COMT failed to influence the hypoxic response. Ho…

medicine.medical_specialtyCatechol-O-methyl transferaseEndogenyHypoxic ventilatory responseHypoxia (medical)chemistry.chemical_compoundmedicine.anatomical_structureEndocrinologyDebrisoquinechemistryDopamineInternal medicinemedicineCarotid bodyEntacaponemedicine.symptommedicine.drug
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The COMT val158met Polymorphism Is Associated with Early Pubertal Development, Height and Cortical Bone Mass in Girls

2005

Estrogens are involved in accretion of bone mass during puberty. Catechol-O-Methyltransferase (COMT) is involved in the degradation of estrogens. In this cross-sectional study we investigated associations between the COMT val158met polymorphism, which results in a 60-75% difference in enzyme activity between the val (high activity = H) and the met (low activity = L) variant, and skeletal phenotypes in 246 healthy pre/early pubertal girls. Girls with COMT(LL) were 5.4 cm taller than COMT(HH) girls. Dual x-ray absorptiometry showed higher values of bone mineral content (BMC), and larger areas of total body, femur and spine in COMT(LL). Cortical BMC, measured by peripheral quantitative compute…

medicine.medical_specialtyGenotypeBone densitymedicine.medical_treatmentCatechol O-Methyltransferasebehavioral disciplines and activitiesBone and BonesInsulin-like growth factorAbsorptiometry PhotonMethionineBone DensityInternal medicinemental disordersGenotypemedicineHumansFemurTibiaChildBone mineralPolymorphism GeneticCatechol-O-methyl transferaseEstradiolbusiness.industryPubertyfungiEstrogensValineBody HeightPhenotypemedicine.anatomical_structureEndocrinologynervous systemPediatrics Perinatology and Child HealthBody CompositionRegression AnalysisFemaleCortical boneTomography X-Ray ComputedbusinessPediatric Research
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